Influenza is an important vaccine preventable infection, which is an annual global health threat. Huge advances have been made in our knowledge of the influenza virus and as a consequence the ability to produce more effective influenza vaccines. In the last few years, the Joint Committee on Vaccination and Immunisation (JCVI) has considered newly licensed influenza vaccines for use in the UK population. The UK now has a differentiated influenza immunisation programme with different vaccines being advised for different risk groups. Currently, the various vaccines are differentiated by age, but in the future may also be differentiated by risk group. General practice nurses (GPNs) need to understand how these various influenza vaccines differ, what are their advantages in terms of the increased protection they offer to patients, and, in turn, be able to explain these advantages to patients.