The terms sexually transmitted diseases and sexually transmitted infections (STIs) are used to cover a number of individual conditions that vary in their presentation, treatment, management and risk, and severity of complications. Statistics indicate that the prevalence of some diseases is rising, while others are falling. Yet, in spite of these findings, in 2017 there were 422,147 new diagnoses of STIs made in England alone (Public Health England [PHE], 2018). Current data shows that young people experience the highest diagnosis rates, thought to be likely due to more frequent rates of partner change among younger adults, with females more likely to be diagnosed than males (PHE, 2018). Early detection and treatment is key if complications and avoidance of spread are to be achieved. Given the incidence of some STIs, it is likely that general practice nurses (GPNs) and GPs will be approached by patients asking for help and advice. This article gives an overview of some of the more common STIs, with the aim of improving knowledge and confidence in this area of clinical practice.