Oral disease can significantly impact systemic health, and vice versa. This article highlights the potential mechanisms of how gum disease (periodontitis) and root canal infection may exacerbate various chronic illnesses, such as cardiovascular disease, diabetes and dementia. The bi-directional relationship is discussed whereby immune-compromised patients may experience poor healing after dental treatment. As many oral diseases are preventable, oral healthcare professionals can play a vital role in improving awareness and educating patients on the association between good oral health and their general health. Greater interdisciplinary collaboration is key to improving patient care.