Self-harm has increased significantly over the past few years. The restrictions due to the Covid pandemic are thought to be a contributing trigger for an individual to self-harm. Patients who present to healthcare systems with self-harm injuries can be met with indifference and lack of understanding by healthcare professionals who do not have the knowledge and skills to deal with individuals who have complex mental health needs. General practice nurses (GPNs) who care for patients with self-harm injuries should be able to offer empathy, understanding, and know how to refer and signpost to ensure that timely intervention can be made to the most appropriate mental health team or allied worker. This article explores how Covid-19 has impacted on self-harm, the important aspects of assessment to consider when a patient presents with a self-harm injury, and discusses interventions that may assist in the management of such wounds in clinical practice