General practice nurses (GPNs) play a critical role in supporting the health and well-being of culturally and linguistically diverse patients. This paper reports on a review and synthesis of qualitative research exploring the experiences and perspectives of GPNs caring for culturally and linguistically diverse patients. Three electronic databases were
systematically and comprehensively searched. Searches were limited to articles published in English language between 2012 and 2022. The title/abstract and full text articles were independently double screened. Qualitative findings are presented in themes and reported narratively. Eight studies met the inclusion criteria reporting perspectives of 60  GPNs working across seven different countries. Three themes were generated;  experiencing uncertainties, developing crosscultural communication skills and limitations in cultural knowledge. The findings of this review highlight the intricacies of adapting nursing practices to meet the needs of culturally and linguistically diverse patients. Strengthening the commitment to providing culturally responsive care at both individual and organisational levels is paramount.