For the purpose of this article, the long-term conditions covered in relation to hypertension are diabetes, asthma/chronic obstructive pulmonary disease (COPD), autoimmune rheumatic diseases and inflammatory bowel disease (Crohn’s/colitis), which for general practice nurses (GPNs) are often managed routinely in daily practice. This article not only explores why monitoring is required while reviewing the diagnosis of hypertension and long-term conditions, but also considers the impact on existing disease trajectories. In addition, both pharmacological and non- pharmacological measures are discussed for patient-centred care.