Here, Callum Metcalfe-O’Shea, UK professional lead for long-term conditions at the Royal College of Nursing (RCN), provides an overview of the important role that GPNs play in supporting patients living with long-term conditions. The value of GPNs will be explored, as well as the interventions they provide, relationships built between patients and nurses, and how we need to continue championing the GPN role to support the future of patient care.