The mental health and wellbeing of children and young people (CYP) is an area of growing concern, with many experiencing challenges that do not meet the threshold for specialist services but still requiring support. General practice nurses (GPNs) regularly come across young people in their line of work, and those who feel comfortable doing so may be well-positioned to provide some support in this area — be it opportunistically if mental health concerns are identified as part of another presentation, or as the focus of a consultation. Building on the discussion of assessment and referral processes in a previous article (Al-Yassin, 2024), this piece explores practical strategies for supporting CYP with mental health concerns. It describes the widely adopted THRIVE Framework and how the role of the GPN fits into this with a focus on the ‘thriving’ and ‘getting advice’ quadrants. This article introduces for the first time the 6S technique, including stigma reduction, simple explanations, self-help, signposting, support and safety netting, and provides comprehensive resources and signposting to guide both new and experienced GPNs in supporting the mental health of CYP.